Calcium Handling Abnormalities as a Target for Atrial Fibrillation Therapeutics: How Close to Clinical Implementation?
| Autor: | Niels Voigt, Shokoufeh Ghezelbash, Ilona Schirmer, Dobromir Dobrev, Jordi Heijman |
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| Přispěvatelé: | RS: CARIM School for Cardiovascular Diseases, RS: CARIM - R2 - Cardiac function and failure, Cardiologie |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Calcium handling Medizin Drug Delivery Systems Internal medicine Atrial Fibrillation medicine Animals Humans Calcium Signaling Adverse effect Atrial ectopic Pharmacology Proarrhythmia business.industry Cardiac arrhythmia Atrial fibrillation Reentry Calcium Channel Blockers medicine.disease Cardiology Calcium Calcium Channels Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents Atrial Remodeling |
| Zdroj: | Journal of Cardiovascular Pharmacology, 66(6), 515-522. LIPPINCOTT WILLIAMS & WILKINS |
| ISSN: | 0160-2446 |
| Popis: | Atrial fibrillation (AF) is the most common cardiac arrhythmia with a substantial impact on morbidity and mortality. Antiarrhythmic drugs play a major role in rhythm-control therapy of AF. However, currently available agents exhibit limited efficacy and pronounced adverse effects, notably drug-induced proarrhythmia. Recent experimental studies have identified that Ca handling abnormalities are critical elements in AF pathophysiology with central roles in atrial ectopic activity, reentry, and atrial remodeling suggesting that Ca handling abnormalities could be promising targets for novel AF therapeutics. Here, we summarize key aspects of AF-related Ca-handling abnormalities, describe currently available compounds targeting atrial Ca handling, and highlight potential novel targets and experimental drugs currently under investigation. Finally, we assess how close AF therapeutics based on Ca-handling abnormalities are to clinical implementation. |
| Databáze: | OpenAIRE |
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