Effect of alcohol consumption on whole-body protein turnover in healthy adults
| Autor: | Klaus D. Wutzke, G Bruns, Marianne Wigger |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Alcohol Drinking Medicine (miscellaneous) Wine Alcohol Saccharomyces cerevisiae Urine medicine.disease_cause Mass Spectrometry Inorganic Chemistry Young Adult chemistry.chemical_compound Animal science Internal medicine Germany medicine Humans Environmental Chemistry Feces General Environmental Science Nutrition and Dietetics Chromatography Ethanol Nitrogen Isotopes business.industry Protein turnover Proteins Oxidative Stress Endocrinology chemistry Female Liver function Whole body business Alcohol consumption Oxidative stress |
| Zdroj: | Isotopes in Environmental and Health Studies. 47:26-33 |
| ISSN: | 1477-2639 1025-6016 |
| DOI: | 10.1080/10256016.2011.557724 |
| Popis: | The aim of the study was to investigate the whole-body protein turnover, either before or after continuous, moderate ethanol-induced oxidative stress by red wine consumption over a relatively short period in healthy volunteers. Ten healthy adults received an individual regular diet over 20 days. After 10 days, the subjects consumed 0.4 ml ethanol kg(-1) day(-1) as red wine together with dinner over a 10-day period. After 8 and 18 days, respectively, a (15)N-labelled yeast protein was administered in a dosage of 4.2 mg kg(-1) body weight. Urine and faeces were collected over 48 h, respectively. The (15)N-enrichment was measured by isotope ratio mass spectrometry, whereas the protein flux rates were calculated by a three-compartment model. The whole-body protein turnover without/with red wine consumption amounted to 3.73±0.6 and 3.49±0.6 g kg(-1) day(-1) (not significant), respectively. Moderate alcohol consumption does not induce significant short-term changes in the whole-body protein turnover of healthy adults. |
| Databáze: | OpenAIRE |
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