The influence of fullerenol on antioxidative enzyme activity in irradiated human erythroleukemic cell line (K562)

Autor: Aleksandar Djordjevic, Visnja Bogdanovic, Ivana Icevic, Gordana Bogdanović, Aleksandra Nikolic, Slavica Šolajić, Karmen Stankov
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Zdroj: Hemijska Industrija, Vol 61, Iss 3, Pp 164-166 (2007)
Popis: Cell culture K562 samples were treated with fullerenol (C6o(OH)24) at a concentration of 10 nmol/mL and thereafter irradiated with X-rays (24Gy). The activity of gamma-glutamyltransfrease (?-GT), total superoxide-dismutase (SOD) and glutathion-peroxidase (GSH-Px) was determined 1, 24 and 48 hours after irradiation. Irradiation induces an increase in the activity of all the investigated enzymes. Fullerenol in the applied dose decreased the ?-GT activity 24 and 48 h after irradiation. The total SOD activity is increased in both pretreated groups except in the iradiated group at the 48th hour. Treatment with fullerenol before irradiation increased GSH-Px activity in irradiated groups and decreased it in the control groups.
Databáze: OpenAIRE