Comparing the effects of cryotherapy with nitrous oxide gas versus topical corticosteroids in the treatment of oral lichen planus
| Autor: | Hooman Ebrahimi, Sara Pourshahidi, Zahra Ranjbar, D Amanat, Nasim Zeini, Maryam Zahed Zahedani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty corticosteroid Triamcinolone acetonide Visual analogue scale medicine.drug_class medicine.medical_treatment Administration Topical Nitrous Oxide Cryotherapy law.invention oral lichen planus Randomized controlled trial stomatognathic system law Adjuvant therapy medicine Humans Oral mucosa General Dentistry Glucocorticoids Pain Measurement business.industry General Medicine topical administration medicine.disease Dermatology Surgery lcsh:RK1-715 stomatognathic diseases medicine.anatomical_structure Treatment Outcome lcsh:Dentistry Corticosteroid Patient Compliance Oral lichen planus Female business medicine.drug Lichen Planus Oral |
| Zdroj: | Indian Journal of Dental Research, Vol 25, Iss 6, Pp 711-716 (2014) |
| ISSN: | 1998-3603 0970-9290 |
| Popis: | Background: Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa with treatment challenges for clinicians. Aims: The objective of this study is to compare the effects of cryotherapy as a new modality with topical corticosteroids as a conventional therapy in the treatment of OLP. Materials and Methods: Thirty patients with bilateral OLP lesions were selected. From each patient a lesion on one side was chosen randomly for a single session of cryotherapy with nitrous oxide gas and the lesion on the other side received triamcinolone acetonide 0.1% ointment in orabase. Treatment outcome was measured by means of an appearance score, pain score (visual analogue scale), and severity of lesions before treatment and after 2, 4 and 6 weeks of treatment. Statistical Analysis Used: Paired samples t-test and Wilcoxon test. Results: In both methods of treatment sign score, pain score and severity of lesions was significantly reduced in all follow-up sessions (P < 0.05). But the treatment outcome and relapse was not significantly different between the two treatment methods (P > 0.05). Conclusion: Cryotherapy with nitrous oxide gas is as effective as topical triamcinolone acetonide in the treatment of OLP with no systemic side effects and needs less patient compliance. It can be considered as an alternative or adjuvant therapy in OLP patients to reduce the use of treatments with adverse effects. |
| Databáze: | OpenAIRE |
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