Effects of three different dose regimens of magnesium on propofol requirements, haemodynamic variables and postoperative pain relief in gynaecological surgery
| Autor: | Seyit Mehmet Kayacan, Kamil Pembeci, K. Akpir, Mehmet Tugrul, M.O. Sungur, L. Telci, Tülay Özkan Seyhan |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_treatment chemistry.chemical_element Hysterectomy Drug Administration Schedule Fentanyl Magnesium Sulfate Bolus (medicine) Double-Blind Method Heart Rate Infusion Procedure Medicine Humans Saline Propofol Pain Postoperative Dose-Response Relationship Drug Morphine business.industry Magnesium Analgesia Patient-Controlled Analgesics Non-Narcotic Middle Aged Analgesics Opioid Anesthesiology and Pain Medicine chemistry Anesthesia Bispectral index Anesthesia Recovery Period Atracurium Female business Anesthetics Intravenous medicine.drug Neuromuscular Nondepolarizing Agents |
| Zdroj: | British journal of anaesthesia. 96(2) |
| ISSN: | 0007-0912 |
| Popis: | Background In this double-blind, randomized, placebo-controlled study we compared the effects of three different dose regimens of magnesium on intraoperative propofol and atracurium requirements, and postoperative morphine consumption in patients undergoing gynaecological surgery. Methods Eighty women were allocated to four equal groups. The control group received normal saline; magnesium groups received 40 mg kg−1 of magnesium before induction of anaesthesia, followed by i.v. infusion of normal saline, magnesium 10 mg kg−1 h−1 or magnesium 20 mg kg−1 h−1 for the next 4 h. Propofol infusion was targeted to keep bispectral index values between 45 and 55. Postoperative analgesia was achieved using PCA with morphine. Results Magnesium groups required significantly less propofol [mean (sd) 121.5 (13.3), 102.2 (8.0) and 101.3 (9.7) μg kg−1 min−1 respectively] than the control group (140.7 (16.5) μg kg−1 min−1). Atracurium use was significantly higher in the control group than magnesium groups [0.4 (0.06) vs 0.34 (0.06), 0.35 (0.04), 0.34 (0.06) mg kg−1 h−1 respectively]. Morphine consumption was significantly higher in control group than magnesium groups on the first postoperative day [0.88 (0.14) vs 0.73 (0.17), 0.59 (0.23), 0.53 (0.21) mg kg−1 respectively]. The heart rate was lower in magnesium groups and 20 mg kg−1 h−1 infusion group demonstrated the lowest values. Conclusion Magnesium 40 mg kg−1 bolus followed by 10 mg kg−1 h−1 infusion leads to significant reductions in intraoperative propofol, atracurium and postoperative morphine consumption. Increasing magnesium dosage did not offer any advantages, but induced haemodynamic consequences. |
| Databáze: | OpenAIRE |
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