Interactions of Ofloxacin and Erythromycin with the Multidrug Resistance Protein (MRP) in MRP-Overexpressing Human Leukemia Cells
| Autor: | Mikio Oka, Kazuhiro Tsukamoto, Takashi Nakamura, Minoru Fukuda, Chuwa Tei, Mitsuhiro Suenaga, Ken Shiozawa, Shigeru Kawabata, Hiroshi Soda, Yuji Noguchi, Katsumi Nakatomi, Kenji Terashi, Shigeru Kohno |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Ofloxacin
Vincristine Pharmacology chemistry.chemical_compound stomatognathic system Tumor Cells Cultured medicine Humans heterocyclic compounds Drug Interactions Pharmacology (medical) ATP Binding Cassette Transporter Subfamily B Member 1 P-glycoprotein Leukemia biology Fluoresceins Antimicrobial Antineoplastic Agents Phytogenic Erythromycin Calcein Multiple drug resistance Infectious Diseases chemistry biology.protein Efflux Genes MDR Intracellular medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 44:1697-1700 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.44.6.1697-1700.2000 |
| Popis: | To investigate interactions between the multidrug resistance protein (MRP) and antimicrobial agents, we examined the effects of 12 agents on vincristine sensitivity and efflux of the calcein acetoxy-methyl ester (calcein-AM) of a MRP substrate in MRP-overexpressing cells. Only ofloxacin and erythromycin enhanced sensitivity with increased intracellular vincristine accumulation and inhibited the calcein-AM efflux. Our findings suggest that the two agents are possible MRP substrates and may competitively inhibit MRP function as a drug efflux pump. |
| Databáze: | OpenAIRE |
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