Liver resection in elderly patients with extensive CRLM: Are we offering an adequate treatment? A propensity score matched analysis

Autor: Marcello Di Martino, Dimitri Dorcaratto, Florian Primavesi, Nicholas Syn, Lara Blanco-Terés, Aurélien Dupré, Tullio Piardi, Rami Rhaiem, Gerardo Blanco Fernández, Noelia De Armas Conde, Juan Carlos Rodríguez Sanjuán, Roberto Fernández Santiago, María-Carmen Fernández-Moreno, Georgina Ferret, Santiago López Ben, Miguel Ángel Suárez Muñoz, Alejandro J. Perez-Alonso, Ye-Xin Koh, Robert Jones, Giovanni Vennarecci, Elena Martín-Pérez
Rok vydání: 2022
Předmět:
Zdroj: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
ISSN: 0748-7983
1532-2157
Popis: BACKGROUND: Data on the management of elderly patients with extensive colorectal liver metastases (CRLM) are scarce and conflicting. This study assesses differences in management and long-term oncological outcomes between older and younger patients with CRLM and a high Tumour Burden Score (TBS).; METHODS: International multicentre retrospective study on patients with CRLM and a category 3 TBS, submitted to liver resection. Patients were divided into two groups according to their age (younger and older than 75) and were compared using propensity score matching (PSM) analysis and multivariable regression models. Differences in management and oncological outcomes including recurrence-free survival (RFS) and overall survival (OS) were assessed.; RESULTS: The study included 386 patients, median follow-up was 48 months. The unmatched comparison revealed a higher ASA score (p=0.035), less synchronous CRLM (47% vs 68%, p=0.003), a lower median number of lesions (1 vs 3, p=0.004) and less perioperative chemotherapy (CTx) (66% vs 88%, p
Databáze: OpenAIRE