Effect of sub-inhibitory concentrations of antibiotics on the virulence ofStaphylococcus aureus
| Autor: | G.S. Tillotson, S.A. Doss, Sebastian G. B. Amyes |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Coagulase
Staphylococcus aureus Dose-Response Relationship Drug Virulence Tetracycline medicine.drug_class Chloramphenicol Antibiotics Hemolysin Microbial Sensitivity Tests Biology medicine.disease_cause Applied Microbiology and Biotechnology Microbiology Anti-Bacterial Agents Hemolysin Proteins medicine Enoxacin Staphylococcal Protein A medicine.drug |
| Zdroj: | Journal of Applied Bacteriology. 75:123-128 |
| ISSN: | 0021-8847 |
| DOI: | 10.1111/j.1365-2672.1993.tb02756.x |
| Popis: | The production of virulence factors by various bacteria can be influenced by sub-inhibitory concentrations of antibiotics. The effect of six antibiotics on the production of representative extracellular enzymes and toxins produced by Staphylococcus aureus was investigated. The production of the virulence determinants coagulase, protein A, alpha and delta haemolysin was monitored in the presence of ciprofloxacin, enoxacin, chloramphenicol, gentamicin, tetracycline and methicillin. The protein synthesis inhibitors reduced the production of coagulase and protein A, and almost completely inhibited the production of the haemolysins. Haemolysin production was also reduced by ciprofloxacin and enoxacin, but these antibiotics had little effect on the production of coagulase and protein A. Methicillin stimulated the production of alpha and delta haemolysins but had no effect on the production of coagulase and protein A. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text