Isoliquiritigenin suppresses pulmonary metastasis of mouse renal cell carcinoma
| Autor: | Akihiko Tokue, Hitoshi Endo, Masaki Baba, Shoji Yamazaki, Toshiro Hamamoto, Toru Okuyama, Yoshiko Joichi, Sanae Kaneko, Tatuo Morita, Hoyoku Nishino, Yoshihito Okada |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Lipopolysaccharides
Male Cancer Research medicine.medical_specialty Lung Neoplasms Antineoplastic Agents Nitric Oxide Nitric oxide Metastasis Metastasis Suppression Mice chemistry.chemical_compound Chalcone Chalcones Leukocytopenia Internal medicine Weight Loss Glycyrrhiza Tumor Cells Cultured medicine Carcinoma Animals Enzyme Inhibitors Cytotoxicity Carcinoma Renal Cell Mice Inbred BALB C Dose-Response Relationship Drug Cell growth business.industry Macrophages Leukopenia medicine.disease Kidney Neoplasms Endocrinology Oncology chemistry Cancer research Fluorouracil business Isoliquiritigenin Phytotherapy |
| Zdroj: | Cancer Letters. 183:23-30 |
| ISSN: | 0304-3835 |
| Popis: | Isoliquiritigenin is a chalcone isolated from licorice and shallots. The ability of isoliquiritigenin to suppress metastasis was examined in a pulmonary metastasis model of mouse renal cell carcinoma. Isoliquiritigenin significantly reduced pulmonary metastasis, without any weight loss or leukocytopenia. Isoliquiritigenin suppressed in vitro proliferation of carcinoma cells, potentiated nitric oxide production by lipopolysaccharide-stimulated macrophages, and facilitated cytotoxicity of splenic lymphocytes in vitro. These findings suggest activation of macrophages, activation of cytotoxicity of lymphocytes, and direct cytotoxicity as possible mechanisms of metastasis suppression by isoliquiritigenin. In addition, isoliquiritigenin prevented severe leukocytopenia caused by administration of 5-fluorouracil. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect