Miniaturized Synthetic Palmitoylation Motifs for Small-Molecule Localization in Living Cells

Autor:	Sachio Suzuki, Masaru Yoshikawa, Shunsuke Sawada, Neal K. Devaraj, Shinya Tsukiji
Rok vydání:	2022
Předmět:	Pharmacology Organic Chemistry Biomedical Engineering Pharmaceutical Science Bioengineering Biotechnology
Zdroj:	Bioconjugate Chemistry. 34:169-173
ISSN:	1520-4812 1043-1802
DOI:	10.1021/acs.bioconjchem.2c00517
Popis:	Conjugating small-molecule ligands to synthetic motifs that can localize to specific organelles or membranes in living cells is a practical approach to develop compounds as chimeric tools or drugs that can manipulate biological processes in a subcellular site-specific manner. However, the number of available organelle-targeted synthetic motifs for small-molecule localization is limited. We have recently developed a synthetic myristoyl
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2107ef7f75a65adcfd4de356a1c47f5d https://doi.org/10.1021/acs.bioconjchem.2c00517 Zobrazit plný text záznamu