Characteristics and outcome of adult patients with acute promyelocytic leukemia and increased body mass index treated with the PETHEMA Protocols
Autor: | Javier de la Serna, Pau Montesinos, Jose D. González-Sanmiguel, Manuel Pérez-Encinas, Salut Brunet, Marta Sobas, Flor García-Álvarez, Isolda Fernández, Marcos González, Cristina Gil, Josep-Maria Ribera, Miguel A. Sanz, José González-Campos, Monika Paluszewska, Celina Benavente, Olga Salamero, Mar Tormo, Bob Löwenberg, Félix Manso, Edo Vellenga, Jordi Esteve, Rebeca Rodríguez-Veiga, Juan Bergua |
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Přispěvatelé: | European Commission, Centro de Investigación Biomédica en Red Cáncer (España), Instituto de Investigación Sanitaria La Fe (España), Stem Cell Aging Leukemia and Lymphoma (SALL), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Hematology |
Rok vydání: | 2020 |
Předmět: |
Male
Multivariate analysis Overweight TOXICITY Body Mass Index 0302 clinical medicine Leukemia Promyelocytic Acute Recurrence Acute promyelocytic leukemia Antineoplastic Combined Chemotherapy Protocols DIFFERENTIATION SYNDROME Outcome Aged 80 and over AIDA protocol Mercaptopurine Mortality rate Incidence (epidemiology) Hematology General Medicine Middle Aged Prognosis Treatment Outcome Vincristine Population Surveillance 030220 oncology & carcinogenesis Female medicine.symptom Underweight Adult medicine.medical_specialty Adolescent ACUTE MYELOID-LEUKEMIA DIAGNOSIS Young Adult 03 medical and health sciences Internal medicine medicine Asparaginase Humans Obesity Risk factor Aged RESPONSE CRITERIA OVERWEIGHT business.industry nutritional and metabolic diseases ANTHRACYCLINE medicine.disease RISK-ADAPTED TREATMENT Methotrexate TRANS-RETINOIC ACID Prednisone business Body mass index 030215 immunology |
Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname European Journal of Haematology, 104(3), 162-169. Wiley European Journal of Haematology, 104, 162-169. Wiley-Blackwell Publishing Ltd |
ISSN: | 1600-0609 0902-4441 |
Popis: | PETHEMA, HOVON, PALG, GATLA cooperative groups. [Objective] The obesity/overweight may have an influence on APL outcomes. [Methods] This is the biggest multicentre analysis on 1320 APL patients treated with AIDA‐induction and risk‐adapted consolidation between 1996 and 2012. Patients body mass index (BMI) was classified as underweight ( [Results and conclusions] Relationship between male gender, older age, and other known laboratory abnormalities in overweight/obese patients was significant. The induction mortality rate was significantly higher in APL with BMI ≥25 vs BMI This work was partially financed with FEDER funds (CIBERONC (CB16/12/00284)) and with Instituto de Investigación Sanitaria La Fe funds (2014/0368). |
Databáze: | OpenAIRE |
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