Characteristics and outcome of adult patients with acute promyelocytic leukemia and increased body mass index treated with the PETHEMA Protocols

Autor: Javier de la Serna, Pau Montesinos, Jose D. González-Sanmiguel, Manuel Pérez-Encinas, Salut Brunet, Marta Sobas, Flor García-Álvarez, Isolda Fernández, Marcos González, Cristina Gil, Josep-Maria Ribera, Miguel A. Sanz, José González-Campos, Monika Paluszewska, Celina Benavente, Olga Salamero, Mar Tormo, Bob Löwenberg, Félix Manso, Edo Vellenga, Jordi Esteve, Rebeca Rodríguez-Veiga, Juan Bergua
Přispěvatelé: European Commission, Centro de Investigación Biomédica en Red Cáncer (España), Instituto de Investigación Sanitaria La Fe (España), Stem Cell Aging Leukemia and Lymphoma (SALL), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Hematology
Rok vydání: 2020
Předmět:
Male
Multivariate analysis
Overweight
TOXICITY
Body Mass Index
0302 clinical medicine
Leukemia
Promyelocytic
Acute
Recurrence
Acute promyelocytic leukemia
Antineoplastic Combined Chemotherapy Protocols
DIFFERENTIATION SYNDROME
Outcome
Aged
80 and over
AIDA protocol
Mercaptopurine
Mortality rate
Incidence (epidemiology)
Hematology
General Medicine
Middle Aged
Prognosis
Treatment Outcome
Vincristine
Population Surveillance
030220 oncology & carcinogenesis
Female
medicine.symptom
Underweight
Adult
medicine.medical_specialty
Adolescent
ACUTE MYELOID-LEUKEMIA
DIAGNOSIS
Young Adult
03 medical and health sciences
Internal medicine
medicine
Asparaginase
Humans
Obesity
Risk factor
Aged
RESPONSE CRITERIA
OVERWEIGHT
business.industry
nutritional and metabolic diseases
ANTHRACYCLINE
medicine.disease
RISK-ADAPTED TREATMENT
Methotrexate
TRANS-RETINOIC ACID
Prednisone
business
Body mass index
030215 immunology
Zdroj: Digital.CSIC. Repositorio Institucional del CSIC
instname
European Journal of Haematology, 104(3), 162-169. Wiley
European Journal of Haematology, 104, 162-169. Wiley-Blackwell Publishing Ltd
ISSN: 1600-0609
0902-4441
Popis: PETHEMA, HOVON, PALG, GATLA cooperative groups.
[Objective] The obesity/overweight may have an influence on APL outcomes.
[Methods] This is the biggest multicentre analysis on 1320 APL patients treated with AIDA‐induction and risk‐adapted consolidation between 1996 and 2012. Patients body mass index (BMI) was classified as underweight (
[Results and conclusions] Relationship between male gender, older age, and other known laboratory abnormalities in overweight/obese patients was significant. The induction mortality rate was significantly higher in APL with BMI ≥25 vs BMI
This work was partially financed with FEDER funds (CIBERONC (CB16/12/00284)) and with Instituto de Investigación Sanitaria La Fe funds (2014/0368).
Databáze: OpenAIRE
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