Stability of Colistimethate Sodium in Aqueous Solution
| Autor: | Edward J. Fuchs, Robert A. Salata, J. M. Griffiss, Jeffrey L. Blumer, Wesley A. Gray, Amanda M. Healan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.drug_class
Polymyxin Drug Compounding Clinical Therapeutics Microbiology Nephrotoxicity Vaccine Related Hydrolysis Drug Stability Tandem Mass Spectrometry medicine Pharmacology (medical) Pharmaceutical Solutions Pharmacology Polymyxin E2 Aqueous solution Chromatography Chemistry Colistin Temperature Water Pharmacology and Pharmaceutical Sciences Anti-Bacterial Agents Infectious Diseases Medical Microbiology lipids (amino acids peptides and proteins) Colistimethate Sodium medicine.drug |
| Zdroj: | Antimicrobial agents and chemotherapy, vol 56, iss 12 |
| Popis: | Colistimethate sodium, increasingly used to treat multidrug-resistant Gram-negative infections, spontaneously hydrolyzes to form colistin A (polymyxin E1) and B (polymyxin E2/B) when mixed with water. High levels of these active breakdown products at the time of administration have been associated with nephrotoxicity and even death. In this study, reconstituted colistimethate sodium was shown to be stable ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|