Primary hepatic lymphoma in a man with chronic hepatitis C
| Autor: | J.C. O'Keane, Grace Callagy, John Crowe, G. Clarke, Padraic MacMathuna, Carney D, Fenlon H |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Pathology medicine.medical_specialty Abdominal pain Lymphoma B-Cell Antibodies Neoplasm Biopsy Enzyme-Linked Immunosorbent Assay Hepacivirus Polymerase Chain Reaction Virus Fatal Outcome immune system diseases hemic and lymphatic diseases Medicine Humans Gastrointestinal tract Hepatology biology business.industry Liver Neoplasms Gastroenterology Hepatitis C Helicobacter pylori Hepatitis C Antibodies Middle Aged biology.organism_classification medicine.disease Lymphoma Chronic infection Chronic Disease RNA Viral Viral disease medicine.symptom business Tomography X-Ray Computed |
| Zdroj: | European journal of gastroenterologyhepatology. 9(1) |
| ISSN: | 0954-691X |
| Popis: | We report the case of a middle-aged man who presented de novo with abdominal pain and hepatomegaly and was found to have positive serology for hepatitis C and subsequently a primary hepatic lymphoma. An increased incidence of primary hepatocellular cancer is well characterized in both cirrhotic and non-cirrhotic cases of chronic hepatitis C. The relationship between chronic hepatitis C and primary hepatic lymphoma remains obscure. It has been established that hepatitis C can sustain the clonal B-cell expansion that occurs in associated cryoglobulinaemia, and hepatitis C RNA has been detected within extrahepatic lymphoma tissue. Viral aetiologies for lymphoma are well characterized, such as Epstein-Barr virus (EBV) and human T-cell leukaemia virus (HTLV) I and II. Existing models of chronic infection causing lymphoma within the gastrointestinal tract include that of Helicobacter pylori and mucosa-associated lymphoid tumour of the stomach. Given the relatively low frequency of occurrence it may be prudent to perform a retrospective analysis on past cases of primary hepatic lymphoma in order to determine whether or not hepatitis C was present. |
| Databáze: | OpenAIRE |
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