Restrictive versus Liberal Fluid Therapy for Post-Cesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial
| Autor: | Paula Castro Scherer, Luiz Marcelo Sá Malbouisson, Aline Macêdo Pinheiro, Lucia Andrade, Marcelo Luis Abramides Torres, Fernando Bliacheriene, Rossana Pulcineli Vieira Francisco, Carlo Victor A Varela, Maria José Carvalho Carmona, Wallace Andrino da Silva, Paolo Pelosi |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Medicine (General) Ringer's Lactate 030204 cardiovascular system & hematology Preeclampsia law.invention 03 medical and health sciences R5-920 0302 clinical medicine Fluid therapy Randomized controlled trial Lipocalin-2 Pre-Eclampsia Serum cystatin law Pregnancy medicine Humans 030212 general & internal medicine Stage (cooking) business.industry Cesarean Section Acute kidney injury General Medicine Acute Kidney Injury medicine.disease Severe preeclampsia female genital diseases and pregnancy complications Regimen Anesthesia Fluid Therapy Original Article Female business Biomarkers |
| Zdroj: | Clinics Clinics, Volume: 75, Article number: e1797, Published: 22 JUL 2020 Clinics; v. 75 (2020); e1797 Clinics; Vol. 75 (2020); e1797 Universidade de São Paulo (USP) instacron:USP Clinics, Vol 75 (2020) |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | OBJECTIVES: The aim of this study was to determine whether a restrictive compared to a liberal fluid therapy will increase postoperative acute kidney injury (AKI) in patients with severe preeclampsia. METHODS: A total of 46 patients (mean age, 32 years; standard deviation, 6.8 years) with severe preeclampsia were randomized to liberal (1500 ml of lactated Ringer’s, n=23) or restrictive (250 ml of lactated Ringer’s, n=23) intravenous fluid regimen during cesarean section. The primary outcome was the development of a postoperative renal dysfunction defined by AKI Network stage ≥1. Serum cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) were evaluated at postoperative days 1 and 2. ClinicalTrials.gov: NCT02214186. RESULTS: The rate of postoperative AKI was 43.5% in the liberal fluid group and 43.5% in the restrictive fluid group (p=1.0). Intraoperative urine output was higher in the liberal (116 ml/h, IQR 69-191) than in the restrictive fluid group (80 ml/h, IQR 37-110, p |
| Databáze: | OpenAIRE |
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