The influence of methylxanthines on precursor incorporation into protein and RNA of mouse brain
| Autor: | I. Boksay, V. Csányi, Judit Gervai, Abel Lajtha |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Time Factors
Mice Inbred Strains Nerve Tissue Proteins Penicillins Brain tissue Pentoxifylline Mice chemistry.chemical_compound Theophylline medicine Protein biosynthesis Animals Cycloheximide Isoleucine Uridine Molecular Biology Chemistry General Neuroscience Brain RNA Aminophylline Animals Newborn Biochemistry Xanthines Streptomycin Neurology (clinical) Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 117:297-304 |
| ISSN: | 0006-8993 |
| Popis: | Pentoxifylline at1mM had no effect on [ 14 C]isoleucine incorporation into mouse brain tissue suspension. At5–20mM, this compound inhibited incorporation. The inhibition was prompt, and it was reversible. Aminophylline at3–12mM produced inhibition, but theophylline at2–16mM had no effect. Pentoxifylline inhibited the incorporation of uridine into brain RNA to the same extent and with a similar time course as its effect on protein synthesis. |
| Databáze: | OpenAIRE |
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