Harnessing nanoparticles to improve toxicity after head and neck radiation
| Autor: | Rafael Madero-Visbal, Beatrice Alvarado, Jimmie Colon, Melissa S. Wason, Beth Isley, Cheryl H. Baker, R. Manon, Chris M. Lee, Sudipta Seal, Soumen Das |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Post-radiation Materials science medicine.medical_treatment Biomedical Engineering Urology Mice Nude Pharmaceutical Science Medicine (miscellaneous) Dermatitis Bioengineering Xerostomia Mice medicine Animals General Materials Science Irradiation Head and neck Saline Skin Radiotherapy business.industry Cerium Radiation therapy Head and Neck Neoplasms Skin hyperpigmentation Toxicity Nanoparticles Molecular Medicine Female Complication Nuclear medicine business |
| Zdroj: | Nanomedicine: Nanotechnology, Biology and Medicine. 8:1223-1231 |
| ISSN: | 1549-9634 |
| Popis: | This article reports the evaluation of cerium oxide (CeO 2 ) nanoparticles' ability to decrease xerostomia and radiation-induced dermatitis in mice after head and neck radiation. Mice were irradiated using an IC160 x-ray system. Two cohorts were included: (A) No-radiation and (B) 30 Gy/6 fractions, and were randomized into three groups: (1) saline, (2) 15 nM CeO 2 and (3) 15 μM CeO 2 . Stimulated salivary flow and radiation-induced dermatitis were evaluated post radiation. Stimulated sialometry demonstrated improved salivary production in all CeO 2 groups in comparison with controls (flow: 204 vs. 115 μL/10 minutes , P = 0.0002). One week post radiation, G-III dermatitis decreased in the 15 μM group in comparison with controls (10% versus 100% incidence, respectively). There was decreased skin hyperpigmentation at 12 weeks in the 15-μM group in comparison with 15-nM and non-CeO 2 groups (50%, 70%, and 90% G-II, respectively). This study suggests that CeO 2 may be radioprotective for salivary production and reduces G-III dermatitis and skin hyperpigmentation incidence. CeO 2 as radioprotectant may be a feasible concept during radiotherapy. From the Clinical Editor This study demonstrates in a mouse model that cerium oxide (CeO 2 ) nanoparticles may provide an important mechanism in preventing radiation induced xerostomia, a common complication of head and neck radiation treatments. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect