Myofibroblast-Mediated Adventitial Remodeling

Autor: Giulio Gabbiani, Matteo Coen, Marie-Luce Bochaton-Piallat
Rok vydání: 2011
Předmět:
Pathology
medicine.medical_specialty
Connective Tissue/pathology/physiopathology
Cell Communication
ddc:616.07
030204 cardiovascular system & hematology
Adventitial fibroblast
03 medical and health sciences
0302 clinical medicine
Restenosis
Fibrosis
Adventitia
Myofibroblasts/pathology/physiology
Cardiovascular Diseases/pathology/physiopathology
Cell Differentiation/physiology
Animals
Humans
Medicine
cardiovascular diseases
Myofibroblasts
Fibroblast
030304 developmental biology
0303 health sciences
business.industry
Cell Differentiation
Fibroblasts/pathology/physiology
Fibroblasts
medicine.disease
Vascular tone
medicine.anatomical_structure
Cardiovascular Diseases
Connective Tissue
Cell Communication/physiology
Tunica Intima/pathology/physiopathology
cardiovascular system
Tunica Intima
Tunica Media
Cardiology and Cardiovascular Medicine
business
Wound healing
Tunica Media/pathology/physiopathology
Myofibroblast
Zdroj: Arteriosclerosis thrombosis and vascular biology
Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 31, No 11 (2011) pp. 2391-6
ISSN: 1524-4636
1079-5642
DOI: 10.1161/atvbaha.111.231548
Popis: The arterial adventitia has been long considered an essentially supportive tissue; however, more and more data suggest that it plays a major role in the modulation of the vascular tone by complex interactions with structures located within intima and media. The purpose of this review is to summarize these data and to describe the mechanisms involved in adventitia/media and adventitia/intima cross-talk. In response to a plethora of stimuli, the adventitia undergoes remodeling processes, resulting in positive (adaptive) remodeling, negative (constrictive) remodeling, or both. The differentiation of the adventitial fibroblast into myofibroblast (MF), a key player of wound healing and fibrosis development, is a hallmark of negative remodeling; this can lead to vessel stenosis and thus contribute to major cardiovascular diseases. The mechanisms of fibroblast-to-MF differentiation and the role of the MF in adventitial remodeling are highlighted herein.
Databáze: OpenAIRE
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