Chitosan treatment for skin ulcers associated with diabetes
Autor: | Olga Rosa Brito-Zurita, Jaime López-Cervantes, José Luis De La Cruz-Mercado, Ana A. Escárcega-Galaz, Dalia I. Sánchez-Machado, José Manuel Ornelas-Aguirre |
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Rok vydání: | 2018 |
Předmět: |
medicine.medical_specialty
medicine.medical_treatment 02 engineering and technology Disease Article Biomaterials Chitosan 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound Diabetes mellitus 0302 clinical medicine Immune system medicine lcsh:QH301-705.5 Ulcer Film Gangrene Gel Agricultural and Biological Sciences(all) integumentary system business.industry Granulation tissue 021001 nanoscience & nanotechnology medicine.disease Dermatology Surgery medicine.anatomical_structure lcsh:Biology (General) chemistry Amputation Toxicity 0210 nano-technology General Agricultural and Biological Sciences business |
Zdroj: | Saudi Journal of Biological Sciences, Vol 25, Iss 1, Pp 130-135 (2018) |
ISSN: | 1319-562X |
Popis: | Infections, ulcerations, gangrene and, in severe cases, extremity amputation, are common complications among diabetic subjects. Various biomaterials have been utilized for the treatment of these lesions. Chitosan is an amino sugar with a low risk of toxicity and immune response. In this study, we evaluated chitosan topical gel and film treatments for subjects with diabetic ulcerations and wounds associated with diabetes mellitus. In a pre-experimental design, we described the result of chitosan gel and film treatment for wounds and skin ulcers among patients with long-standing diabetes mellitus. We studied 8 diabetic patients with wounds and skin ulcers (long duration and Wagner degree 1–2). Initially, most lesions had some degree of infection, tissue damage and ulceration. At the end of the treatment (topical chitosan) period, the infections were cured. All patients experienced a significant improvement in the initial injury and developed granulation tissue and a healthy skin cover. This report represents one of the few published clinical experience regarding the chitosan for the treatment of skin lesions among diabetic subjects. These results are relevant and promising for the treatment of this disease. |
Databáze: | OpenAIRE |
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