Mechanistic Pathways of Malignancy in Breast Cancer Stem Cells
| Autor: | Shiva S. Forootan, Mohammad Hossein Nasr Esfahani, Ali O. Gure, Saghar Yousefnia, Kamran Ghaedi, Farzad Seyed Forootan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research chemotherapy and radiotherapy resistance Angiogenesis Population Review Biology lcsh:RC254-282 Metastasis 03 medical and health sciences angiogenesis 0302 clinical medicine medicine metastasis education Protein kinase B PI3K/AKT/mTOR pathway Hippo signaling pathway education.field_of_study breast cancer stem cell Wnt signaling pathway lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease invasion 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research Stem cell |
| Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 10 (2020) |
| ISSN: | 2234-943X |
| Popis: | Breast cancer stem cells (BCSCs) are the minor population of breast cancer (BC) cells that exhibit several phenotypes such as migration, invasion, self-renewal, and chemotherapy as well as radiotherapy resistance. Recently, BCSCs have been more considerable due to their capacity for recurrence of tumors after treatment. Recognition of signaling pathways and molecular mechanisms involved in stemness phenotypes of BCSCs could be effective for discovering novel treatment strategies to target BCSCs. This review introduces BCSC markers, their roles in stemness phenotypes, and the dysregulated signaling pathways involved in BCSCs such as mitogen-activated protein (MAP) kinase, PI3K/Akt/nuclear factor kappa B (NFκB), TGF-β, hedgehog (Hh), Notch, Wnt/β-catenin, and Hippo pathway. In addition, this review presents recently discovered molecular mechanisms implicated in chemotherapy and radiotherapy resistance, migration, metastasis, and angiogenesis of BCSCs. Finally, we reviewed the role of microRNAs (miRNAs) in BCSCs as well as several other therapeutic strategies such as herbal medicine, biological agents, anti-inflammatory drugs, monoclonal antibodies, nanoparticles, and microRNAs, which have been more considerable in the last decades. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|