Preparation and Characterization of Celecoxib Nanosuspension Using Bead Milling
| Autor: | Dong-Jin Jang, Hee-Cheol Kim, Jun-Pil Jee, Dongjin Kang, Kwan Hyung Cho, Dae-Young Kim, Sung Tae Kim, Hye-In Kim, Yu Chul Kim, Hwa-Mi Lee, Sung-Up Choi, Sang Yeob Park |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
Scanning electron microscope Biomedical Engineering Biological Availability Bioengineering 02 engineering and technology Suspension (chemistry) Suspensions Dynamic light scattering medicine General Materials Science Dissolution testing Particle Size Dissolution General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Bioavailability Solubility Celecoxib Nanoparticles Particle size 0210 nano-technology Nuclear chemistry medicine.drug |
| Zdroj: | Journal of Nanoscience and Nanotechnology. 19:1184-1187 |
| ISSN: | 1533-4880 |
| DOI: | 10.1166/jnn.2019.15917 |
| Popis: | The aim of this study is to develop nanosuspension for improved dissolution of poorly water-soluble celecoxib. We first prepared coarse suspension of celecoxib with Tween 80 and hydroxypropyl methylcellulose as stabilizers, and then fabricated nanosuspension using the bead milling technique. Depending on milling time, the physical properties of nanosuspension were evaluated by photon correlation spectroscopy (e.g., particle size and distribution) and scanning electron microscopy (SEM) (e.g., morphology). As results, the mean size of crystalline celecoxib particles was highly reduced (368.1±14.5 nm) as milling process proceeded comparing to celecoxib powder (6.5±1.0 μm). Morphology of milled celecoxib particles has changed considerably from bar-shape or plate-shape to needle-shape due to a high energy caused by milling. In the dissolution test, the celecoxib nanosuspension showed an improved dissolution profile at pH 1.2 compared to celecoxib powder (less than 1%). In contrast, 53.4% of celecoxib in nanosuspension was dissolved up to 30 minutes, demonstrating improved dissolution of celecoxib. Taken together, bead-milled nanosuspension could be an effective strategy that can improve the dissolution and bioavailability. |
| Databáze: | OpenAIRE |
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