Sinusoidal portal hypertension in hepatic amyloidosis
| Autor: | Jean-Pierre Benhamou, F Maitre, R Brenard, Claude Degott, E A Pariente, Didier Lebrec, E Bion |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Pathology medicine.medical_specialty medicine.diagnostic_test Amyloid business.industry Liver Diseases Amyloidosis Portal venous pressure Hepatic amyloidosis Gastroenterology Hemodynamics Middle Aged medicine.disease Blood pressure Liver biopsy Hypertension Portal Humans Medicine Portal hypertension Female business Research Article Aged |
| Zdroj: | Gut. 32:227-230 |
| ISSN: | 0017-5749 |
| Popis: | Hepatic venous catheterisation and transvenous liver biopsy were performed in five patients with hepatic amyloidosis. In three patients, hepatic venous pressures were normal and histological examination of the liver biopsy specimen showed discrete and sparse perisinusoidal amyloid deposits. In the other two, however, the gradient between wedged and free hepatic venous pressures was increased (12 and 16 mmHg; normal 1-4 mmHg) and amyloid deposits were abundant and diffuse in the Disse's space. This study shows that portal hypertension in patients with hepatic amyloidosis is of the sinusoidal type and is related to the reduction of vascular space of hepatic sinusoids by massive perisinusoidal amyloid deposits. Furthermore, portal hypertension is associated with a poor prognosis in patients with hepatic amyloidosis. |
| Databáze: | OpenAIRE |
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