| Autor: |
Nassr Nama, Parnian Hosseini, Zerlyn Lee, Kara Picco, Jeffrey N Bone, Jessica L Foulds, Josée Anne Gagnon, Anupam Sehgal, Julie Quet, Olivier Drouin, Thuy Mai Luu, Gemma Vomiero, Ronik Kanani, Joanna Holland, Ran D Goldman, Kristopher T Kang, Sanjay Mahant, Falla Jin, Joel S Tieder, Peter J Gill |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
BMJ Open. 12:e063183 |
| ISSN: |
2044-6055 |
| Popis: |
IntroductionBrief Resolved Unexplained Events (BRUEs) are a common presentation among infants. While most of these events are benign and self-limited, guidelines published by the American Academy of Pediatrics inaccurately identify many patients as higher-risk of a serious underlying aetiology (positive predictive value 5%). Recently, new clinical prediction rules have been derived to more accurately stratify patients. This data were however geographically limited to the USA, with no large studies to date assessing the BRUE population in a different healthcare setting. The study’s aim is to describe the clinical management and outcomes of infants presenting to Canadian hospitals with BRUEs and to externally validate the BRUE clinical prediction rules in identified cases.Methods and analysisThis is a multicentre retrospective study, conducted within the Canadian Paediatric Inpatient Research Network (PIRN). Infants (The primary outcome will be the presence of a serious underlying illness. Secondary outcomes will include BRUE recurrence and length of hospital stay. We will describe the rates of hospital admissions and whether hospitalisation was associated with an earlier diagnosis or treatment. Variation across Canadian hospitals will be assessed using intraclass correlation coefficient. To validate the newly developed clinical prediction rule, measures of goodness of fit will be evaluated. For this validation, a sample size of 1182 is required to provide a power of 80% to detect patients with a serious underlying illness with a significance level of 5%.Ethics and disseminationEthics approval has been granted by the UBC Children’s and Women’s Research Board (H21-02357). The results of this study will be disseminated as peer-reviewed manuscripts and presentations at national and international conferences. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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