Oxidative trimerization of indoles via water-assisted visible-light photoredox catalysis and the study of their anti-cancer activities
| Autor: | Bor-Cherng Hong, Chia-Ling Chen, Gene-Hsiang Lee, Li-Ting Cheng, Wen-Shan Li, Sheng-Qi Luo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Indoles
Light Antineoplastic Agents Oxidative phosphorylation Biochemistry Catalysis Structure-Activity Relationship Cell Line Tumor medicine Humans Physical and Theoretical Chemistry Cell Proliferation Indole test Dose-Response Relationship Drug Molecular Structure Chemistry Organic Chemistry Water Photoredox catalysis Cancer Photochemical Processes medicine.disease Combinatorial chemistry Fluorescence Water assisted Drug Screening Assays Antitumor Oxidation-Reduction Human cancer Visible spectrum |
| Zdroj: | Organic & Biomolecular Chemistry. 18:6247-6252 |
| ISSN: | 1477-0539 1477-0520 |
| DOI: | 10.1039/d0ob01298j |
| Popis: | Incorporation of water has been revealed to successfully facilitate visible-light photoredox catalysis of indole leading to increased production of C2-quaternary indolinone. The water-promoted photoreaction of indole under catalyst-free conditions by a household compact fluorescence light was also demonstrated. The antiproliferative activity of the synthesized indolinones was evaluated against three human cancer cell lines. |
| Databáze: | OpenAIRE |
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