Lipids in infectious diseases - The case of AIDS and tuberculosis
| Autor: | Fabrice Dumas, Evert Haanappel |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Tuberculosis Membrane Fluidity 030106 microbiology Biophysics Human immunodeficiency virus (HIV) Biology medicine.disease_cause Biochemistry Immune deficiency syndrome Mycobacterium tuberculosis 03 medical and health sciences Membrane Lipids Drug Delivery Systems Acquired immunodeficiency syndrome (AIDS) Phagocytosis medicine Humans Acquired Immunodeficiency Syndrome Virus Assembly Lipid metabolism Cell Biology Virus Internalization medicine.disease biology.organism_classification Lipid Metabolism Virology Immunology lipids (amino acids peptides and proteins) |
| Zdroj: | Biochimica et biophysica acta. Biomembranes. 1859(9 Pt) |
| ISSN: | 0005-2736 |
| Popis: | Lipids play a central role in many infectious diseases. AIDS (Acquired Immune Deficiency Syndrome) and tuberculosis are two of the deadliest infectious diseases to have struck mankind. The pathogens responsible for these diseases, Human Immunodeficiency Virus-1 and Mycobacterium tuberculosis, rely on lipids and on lipid membrane properties to gain access to their host cells, to persist in them and ultimately to egress from their hosts. In this Review, we discuss the life cycles of these pathogens and the roles played by lipids and membranes. We then give an overview of therapies that target lipid metabolism, modulate host membrane properties or implement lipid-based drug delivery systems. This article is part of a Special Issue entitled: Membrane Lipid Therapy: Drugs Targeting Biomembranes edited by Pablo V. Escriba. |
| Databáze: | OpenAIRE |
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