Comparison of healing in forelimb and hindlimb surgically induced core lesions of the equine superficial digital flexor tendon
| Autor: | Estrada, R J, van Weeren, P R, van de Lest, C H A, Boere, J, Reyes, M, Ionita, J C, Estrada, M, Lischer, C J, Dep Gezondheidszorg Paard, LS Equine Muscoskeletal Biology, LS Veterinaire biochemie, ES TR, Tissue Repair |
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| Přispěvatelé: | Dep Gezondheidszorg Paard, LS Equine Muscoskeletal Biology, LS Veterinaire biochemie, ES TR, Tissue Repair |
| Rok vydání: | 2013 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty animal structures 040301 veterinary sciences medicine.medical_treatment Hindlimb 0403 veterinary science Tendons 03 medical and health sciences Tendon Injuries Forelimb medicine Animals tendinopathy Horses superficial digital flexor tendon Saline Tendon healing Core (anatomy) Wound Healing model General Veterinary Flexor tendon business.industry 04 agricultural and veterinary sciences Anatomy healing medicine.disease horse Tendon Surgery 030104 developmental biology medicine.anatomical_structure Animal Science and Zoology Horse Diseases Tendinopathy business |
| Zdroj: | Veterinary and Comparative Orthopaedics and Traumatology, 27(5), 358. Schattauer GmbH |
| ISSN: | 2567-6911 0932-0814 |
| Popis: | SummaryObjective: Even though equine multi-limb tendinopathy models have been reported, it is unknown if fore- and hindlimb tendon healing behave similarly. The aim of this study was to compare the healing process of surgically induced superficial digital flexor tendon (SDFT) core lesions of fore- and hindlimbs in horses.Methods: Tendon core lesions were surgically induced in the SDFT of both fore- and hindlimbs in eight horses. One randomly assigned forelimb and one randomly assigned hindlimb were injected with saline one and two weeks post-surgery. The healing process was monitored clinically and ultrasonographically. After 24 weeks, the tendons were harvested and biochemical, biomechanical and histological parameters were evaluated.Results: Twenty-four weeks post-surgery, the forelimb SDFT lesions had a significantly higher colour Doppler ultrasound vascularization score (p = 0.02) and glycosaminoglycan concentration (p = 0.04) and a significantly lower hydroxylysylpyridinoline content (p = 0.03).Clinical relevance: Our results indicate that fore- and hindlimb SDFT surgically induced lesions exhibit significant differences in several important parameters of tendon healing 24 weeks post-surgery. These differences create significant challenges in using all four limbs and accurately interpreting the results that one might generate. Therefore these findings do not support the use of four-limb models for study of tendon injury until the reasons for these differences are much better understood. |
| Databáze: | OpenAIRE |
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