Tumor-Suppressor Role of the α1-Na/K-ATPase Signalosome in NASH Related Hepatocellular Carcinoma

Autor:	Utibe-Abasi S. Udoh, Moumita Banerjee, Pradeep K. Rajan, Juan D. Sanabria, Gary Smith, Mathew Schade, Jacqueline A. Sanabria, Yuto Nakafuku, Komal Sodhi, Sandrine V. Pierre, Joseph I. Shapiro, Juan R. Sanabria
Rok vydání:	2022
Předmět:	hepatocellular carcinoma non-alcoholic steatohepatitis α1-Na/K-ATPase PI3K → Akt Pathway FoxO3 signaling pNaKtide Carcinoma Hepatocellular Carcinogenesis Organic Chemistry Liver Neoplasms General Medicine Catalysis Computer Science Applications Inorganic Chemistry Non-alcoholic Fatty Liver Disease Humans Physical and Theoretical Chemistry Sodium-Potassium-Exchanging ATPase Molecular Biology Spectroscopy
Zdroj:	International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 7359
ISSN:	1422-0067
Popis:	Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide, with an estimate of 0.84 million cases every year. In Western countries, because of the obesity epidemic, non-alcoholic steatohepatitis (NASH) has become the major cause of HCC. Intriguingly, the molecular mechanisms underlying tumorigenesis of HCC from NASH are largely unknown. We hypothesized that the growing uncoupled metabolism during NASH progression to HCC, manifested by lower cell redox status and an apoptotic ‘switch’ activity, follows a dysregulation of α1-Na/K-ATPase (NKA)/Src signalosome. Our results suggested that in NASH-related malignancy, α1-NKA signaling causes upregulation of the anti-apoptotic protein survivin and downregulation of the pro-apoptotic protein Smac/DIABLO via the activation of the PI3K → Akt pro-survival pathway with concomitant inhibition of the FoxO3 circuit, favoring cell division and primary liver carcinogenesis. Signalosome normalization using an inhibitory peptide resets apoptotic activity in malignant cells, with a significant decrease in tumor burden in vivo. Therefore, α1-NKA signalosome exercises in HCC the characteristic of a tumor suppressor, suggesting α1-NKA as a putative target for clinical therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f79b221557c85a82b93445a143e748 https://pubmed.ncbi.nlm.nih.gov/35806364 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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