Prognostic value of troponins in acute nonmassive pulmonary embolism: A meta-analysis
| Autor: | Anurag Bajaj, Parul Rathor, Michael Saleeb, Besher Kabak, Vishal Sehgal, Srikanth Hosur |
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| Rok vydání: | 2015 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Blood Pressure Critical Care and Intensive Care Medicine Likelihood ratios in diagnostic testing Internal medicine Clinical endpoint Odds Ratio Medicine Humans Adverse effect Aged biology business.industry Odds ratio Middle Aged medicine.disease Prognosis Troponin Pulmonary embolism Systematic review Meta-analysis Acute Disease biology.protein Cardiology Female Cardiology and Cardiovascular Medicine business Pulmonary Embolism Biomarkers |
| Zdroj: | Heartlung : the journal of critical care. 44(4) |
| ISSN: | 1527-3288 |
| Popis: | The objective of our meta-analysis is to update the evidence on the prognostic value of elevated troponin levels in patient with acute normotensive pulmonary embolism (PE). We did a systematic literature review of database, including Pubmed, EMBASE, and Cochrane. Studies were included if those were done on normotensive patients with acute PE and serum troponin assay was done. The primary end point was short term all cause mortality. The secondary end points were short term PE related mortality and serious adverse events. Elevated troponin levels were significantly associated with the increased risk for short term mortality (odds ratio [OR], 4.80; 95% CI, 3.25-7.08, I(2) = 54%), PE related mortality (OR, 3.80; 95% CI, 2.74-5.27, I(2) = 0%) and serious adverse events (OR, 3.65; 95% CI, 2.41-5.53, I(2) = 47%). Our study suggests that elevated levels of troponin identify a subgroup of patients with increased risk for short term mortality and serious adverse events. |
| Databáze: | OpenAIRE |
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