Influence of polar co-solutes and salt on the hydration of lipid membranes
| Autor: | Emma Sparr, Quoc Dat Pham, Emanuel Schneck, Amanuel Wolde-Kidan, Roland R. Netz, Philip Loche, Alexander Schlaich |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
General Physics and Astronomy
Salt (chemistry) 02 engineering and technology 010402 general chemistry 01 natural sciences Molecular dynamics 500 Naturwissenschaften und Mathematik::540 Chemie::541 Physikalische Chemie Osmotic pressure Molecule salt Osmotic coefficient Physical and Theoretical Chemistry chemistry.chemical_classification Chemistry 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik Sorption 021001 nanoscience & nanotechnology 0104 chemical sciences Membrane Yield (chemistry) Biophysics lipid membranes 0210 nano-technology polar co-solutes |
| Zdroj: | Physical Chemistry Chemical Physics |
| DOI: | 10.1039/c9cp01953g |
| Popis: | The influence of the co-solutes TMAO, urea, and NaCl on the hydration repulsion between lipid membranes is investigated in a combined experimental/simulation approach. Pressure-hydration curves obtained via sorption experiments reveal that the repulsion significantly increases when the membranes are loaded with co-solutes, most strongly for TMAO. As a result, the co-solutes retain additional water molecules and therefore provide membranes with a fluid and more physiological environment. The experimental data are quantitatively reproduced in complementary solvent-explicit atomistic molecular dynamics simulations, which yield the chemical potential of water. Simulation analysis reveals that the additional repulsion arises from the osmotic pressure generated by the co-solutes, an effect which is maximal for TMAO, due to its unfavorable interactions with the lipid headgroup layer and its extraordinarily high osmotic coefficient. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|