Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development
| Autor: | Da-Hai Yu, La Gina Nosavanh, Qiang Tong, Lanlan Shen, Miao-Hsueh Chen, Eric J. Jaehnig |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
animal structures Cellular differentiation Chicken ovalbumin upstream promoter-transcription factor Cell fate determination Biology COUP Transcription Factor II Mice Adipose Tissue Brown Internal medicine Brown adipose tissue medicine Animals Hedgehog Proteins Cilia Hedgehog Multidisciplinary Skeletal muscle Cell Differentiation Biological Sciences Hedgehog signaling pathway Up-Regulation Cell biology Adipocytes Brown medicine.anatomical_structure Endocrinology Signal transduction Signal Transduction |
| Zdroj: | Proceedings of the National Academy of Sciences. 112:5069-5074 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.1420978112 |
| Popis: | Significance The function of brown adipose tissue (BAT), which converts chemical energy into heat, has been widely characterized, but how BAT forms and what signaling molecules regulate its formation are largely unknown. In this paper, we report that Hedgehog (Hh) signaling inhibits the formation of BAT during development. Activation of Hh signaling, specifically in the BAT of mice during development, resulted in the loss of interscapular BAT due to the impairment of brown-preadipocyte differentiation. Remarkably, the majority of the BAT cells in the neck were replaced by skeletal muscle-like cells in embryos with elevated Hh activity. These findings indicate that Hh is an essential regulator of BAT development and that developing BAT depots respond differentially to Hh signaling. |
| Databáze: | OpenAIRE |
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