Preoperative Predictive Factors of Positive Margin Status After Breast Conserving Therapy (BCT) with Intraoperative Radiation Therapy (IORT): A Retrospective Study of 400 Patients
| Autor: | Dabin Ji, William E. Burak, Joshua R. Eskew, Christina Munford, Eric Clayton |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine Cancer Research medicine.medical_specialty medicine.medical_treatment Breast Neoplasms Mastectomy Segmental Logistic regression Intraoperative Period 03 medical and health sciences 0302 clinical medicine Breast cancer Preoperative Care Biopsy Humans Medicine Stage (cooking) Intraoperative radiation therapy Aged Retrospective Studies Aged 80 and over Radiotherapy medicine.diagnostic_test Positive margin business.industry Margins of Excision Retrospective cohort study Odds ratio Middle Aged medicine.disease 030104 developmental biology Oncology 030220 oncology & carcinogenesis Female Radiology Neoplasm Grading Receptors Progesterone business |
| Zdroj: | Clinical Breast Cancer. 20:e618-e622 |
| ISSN: | 1526-8209 |
| Popis: | Introduction Single-fraction intraoperative radiation therapy (IORT) has emerged as a therapeutic option in patients undergoing breast conserving therapy (BCT) for early stage breast cancer, often eliminating the need for postoperative external beam radiation therapy. However, if a positive margin is encountered after BCT, the patient will ultimately require external beam radiation therapy. The purpose of this study was to identify preoperative factors from patient demographics, preoperative workup, or biopsy results that may be predictive of postoperative margin status. Materials and Methods A retrospective chart review was performed on 396 patients who underwent BCT with IORT. Logistic regression models were utilized for statistical analysis. Results The majority of studied variables were similar; however, differences were noted for high-grade tumors, in situ status, and progesterone receptor-negative (PR−) tumors. Grade 3 tumors were significantly associated with positive margin status when compared with Grade 1 (odds ratio, 2.30; P = .036). PR− status tumors were found to be approximately 2 times more likely to have a positive margin (P = .028). Patients with in situ (stage 0) status tumors were 1.986 times more likely to have positive margins when compared with those with an invasive tumor (P = .030). Conclusions Higher grade PR− tumors are at increased risk of having a positive margin, which should be taken into consideration when considering treatment with IORT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect