Toxicology study of long-term administration of rhKGF-2 eye drops on rabbit corneas
| Autor: | Xiaojie Wang, Yadong Huang, Xiaokun Li, Qingde Zhou, Jinghang Li, Wenqing Li, Jianqiu Cai, Qi Hui |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Drug
Male genetic structures medicine.medical_treatment media_common.quotation_subject Administration Ophthalmic 010501 environmental sciences Pharmacology Toxicology 030226 pharmacology & pharmacy 01 natural sciences Cornea 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine Animals Humans Adverse effect 0105 earth and related environmental sciences media_common business.industry Regeneration (biology) Growth factor General Medicine eye diseases medicine.anatomical_structure chemistry Mechanism of action Female sense organs Keratinocyte growth factor Rabbits medicine.symptom Stem cell Ophthalmic Solutions business Fibroblast Growth Factor 10 |
| Zdroj: | Regulatory toxicology and pharmacology : RTP. 103 |
| ISSN: | 1096-0295 |
| Popis: | Keratinocyte growth factor −2 promotes corneal repair. Its mechanism of action involves regulating regeneration and migration of corneal cells, as well as activating corneal limbal stem cells. However, KGF-2 being a carcinogenic growth factor and its potential adverse effect in over dosage long-term treatment had not yet been reported. In this study, we used New Zealand white rabbits to study possible toxic effects of ocular administration of recombinant human keratinocyte growth factor-2 eye drops. Animals in the medium- and high-dose groups had some ocular irritant reactions during the course of drug administration; however this reaction was harmless to the cornea and it ended up when administration was stopped. Serum biochemistries were largely unaffected by treatment. Pathological examinations were unremarkable. We found that over-dosed administration of these eye drops caused some ocular irritation, but this irritant reaction was harmless to the eye, and it reversed after the drug was stopped. There were no apparent systemic effects of the drug. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect