Passive immunization with human anti-protein D antibodies induced by polysaccharide protein D conjugates protects chinchillas against otitis media after intranasal challenge with Haemophilus influenzae

Autor: Laura A. Novotny, Joseph A. Jurcisek, Fabrice Godfroid, Lauren O. Bakaletz, Philippe Denoël, Jan Poolman
Rok vydání: 2006
Předmět:
Zdroj: Vaccine. 24:4804-4811
ISSN: 0264-410X
Popis: Passive transfer of a pediatric human serum pool generated against polysaccharide-protein D conjugate vaccines conferred approximately 34% protection against development of ascending NTHI-induced OM when used in a chinchilla viral-bacterial co-infection model. These data are in line with results obtained using a similar 11-valent-protein D conjugate vaccine in a pediatric clinical trial, wherein a vaccine efficacy of 35.6% was shown against acute OM episodes caused by NTHI. These observations strongly support the chinchilla passive transfer-superinfection model as one that could predict clinical trials outcomes for vaccines to prevent NTHI-induced OM.
Databáze: OpenAIRE