Passive immunization with human anti-protein D antibodies induced by polysaccharide protein D conjugates protects chinchillas against otitis media after intranasal challenge with Haemophilus influenzae
| Autor: | Laura A. Novotny, Joseph A. Jurcisek, Fabrice Godfroid, Lauren O. Bakaletz, Philippe Denoël, Jan Poolman |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Lipoproteins
medicine.disease_cause Haemophilus influenzae Microbiology Bacterial Proteins Chinchilla Conjugate vaccine Nasopharynx otorhinolaryngologic diseases medicine Animals Humans Administration Intranasal Haemophilus Vaccines Vaccines Conjugate General Veterinary General Immunology and Microbiology biology business.industry Immune Sera Polysaccharides Bacterial Pasteurellaceae Immunization Passive Public Health Environmental and Occupational Health Immunoglobulin D biology.organism_classification Vaccine efficacy Antibodies Bacterial Otitis Media Infectious Diseases Otitis Immunization Immunology biology.protein Molecular Medicine Nasal administration medicine.symptom Antibody Carrier Proteins business |
| Zdroj: | Vaccine. 24:4804-4811 |
| ISSN: | 0264-410X |
| Popis: | Passive transfer of a pediatric human serum pool generated against polysaccharide-protein D conjugate vaccines conferred approximately 34% protection against development of ascending NTHI-induced OM when used in a chinchilla viral-bacterial co-infection model. These data are in line with results obtained using a similar 11-valent-protein D conjugate vaccine in a pediatric clinical trial, wherein a vaccine efficacy of 35.6% was shown against acute OM episodes caused by NTHI. These observations strongly support the chinchilla passive transfer-superinfection model as one that could predict clinical trials outcomes for vaccines to prevent NTHI-induced OM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect