Correlation between Topographic Progression of Geographic Atrophy and Visual Acuity Changes
| Autor: | Eung Suk Kim, Jong In You, Do Gyun Kim, Ki-Young Kim, Seung-Young Yu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Fovea Centralis
medicine.medical_specialty Visual acuity genetic structures media_common.quotation_subject Visual Acuity behavioral disciplines and activities Fundus autofluorescence Correlation Foveal Geographic Atrophy Ophthalmology Humans Contrast (vision) Medicine Aged Retrospective Studies media_common business.industry Macular degeneration Mean age General Medicine VISUAL ACUITY DECREASE Geographic atrophy Correlation analysis Original Article Atrophy medicine.symptom business psychological phenomena and processes |
| Zdroj: | Korean Journal of Ophthalmology : KJO |
| ISSN: | 2092-9382 1011-8942 |
| DOI: | 10.3341/kjo.2021.0037 |
| Popis: | Background: To analyze topographic progression of geographic atrophy with different concentric circles centered on the fovea in correlation with decrease of visual acuity. Methods: We retrospectively analysed 36 eyes of 26 patients diagnosed with geographic atrophy and followed at least 1 year. 1mm circular area at the foveal center were defined as Zone 1, and doughnut shape areas from between 1 and 2 mm to between 5 and 6 mm were defined as Zone 2 to Zone 6. Then, changes of geographic atrophy area in each zone were measured with semi-automatic software. Correlation analysis and regression analysis were performed to determine the relationship between changes in visual acuity and atrophic area in each zone. Result: Mean age was 76.9 years and follow-up period were 3.38 years. The mean atrophic area increased from 8.09 to 16.34 mm2 and visual acuity decreased from 0.39 to 0.69 on logMAR. Mean change of total geographic atrophy area was not significantly correlated with visual acuity decrease. While geographic atrophy progression within Zone 1, Zone 2 and Zone 3 showed significant causal relationship with decrease of visual acuity (all p Conclusion: In contrast to the total geographic atrophy area, progression of geographic atrophy in parafoveal area was significantly correlated with decrease of visual acuity. |
| Databáze: | OpenAIRE |
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