Video-Polysomnographic Assessment for the Diagnosis of Disorders of Arousal in Children
| Autor: | Régis Lopez, Christine Laganière, Isabelle Jaussent, Lucie Barateau, Elisa Evangelista, Anna Laura Rassu, Yves Dauvilliers, Sofiène Chenini |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Video recording medicine.medical_specialty Optimal cutoff Receiver operating characteristic business.industry Polysomnography Video Recording Area under the curve Class iii Audiology Confidence interval Arousal 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Sleep Arousal Disorders medicine Humans Cutoff Female Neurology (clinical) Child business 030217 neurology & neurosurgery |
| Zdroj: | Neurology. 96:e121-e130 |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | ObjectivesTo highlight the slow-wave sleep (SWS) fragmentation and validate the video-polysomnographic (vPSG) criteria and cutoffs for the diagnosis of disorders of arousal (DOA) in children, as already reported in adults.MethodsOne hundred children (66 boys, 11.0 ± 3.3 years) with frequent episodes of DOA and 50 nonparasomniac children (32 boys, 10.9 ± 3.9 years) underwent vPSG recording to quantify SWS characteristics (number of N3 sleep interruptions, fragmentation index, slow/mixed and fast arousal ratios, and indexes per hour) and associated behaviors. We compared SWS characteristics in the 2 groups and defined the optimal cutoff values for the diagnosis of DOA using receiver operating characteristic curves.ResultsPatients with DOA had higher amounts of N3 and REM sleep, number of N3 interruptions, SWS fragmentation, and slow/mixed arousal indexes than controls. The highest area under the curve (AUC) values were obtained for SWS fragmentation and slow/mixed arousal indexes with satisfactory classification performances (AUC 0.80, 95% confidence interval [CI] 0.73–0.87; AUC 0.82, 95% CI 0.75–0.89). SWS fragmentation index cutoff value of 4.1/h reached a sensitivity of 65.0% and a specificity of 84.0%. Slow/mixed arousal index cutoff of 3.8/h reached a sensitivity of 69.0% and a specificity of 82.0%. At least one parasomniac episode was recorded in 63.0% of patients and none of the controls. Combining behavioral component by vPSG increased sensitivity of both biomarkers to 83% and 89%, respectively.ConclusionsWe confirmed that SWS fragmentation and slow/mixed arousal indexes are 2 relevant biomarkers for the diagnosis of DOA in children, with different cutoffs obtained than those validated in adults.Classification of EvidenceThis study provides Class III evidence that SWS fragmentation and slow/mixed arousal indexes on vPSG accurately identify children with DOA. |
| Databáze: | OpenAIRE |
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