Soy Isoflavones Protect the Intestine from Lipid Hydroperoxide Mediated Oxidative Damage
| Autor: | Susan L. Cuppett, Subhashinee S.K. Wijeratne |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Lipid Peroxides
Antioxidant DNA damage medicine.medical_treatment Genistein Oleic Acids medicine.disease_cause chemistry.chemical_compound medicine Humans Dose-Response Relationship Drug Daidzein food and beverages General Chemistry Isoflavones Oxidative Stress Oleic acid chemistry Biochemistry Caco-2 Soybeans Caco-2 Cells General Agricultural and Biological Sciences Oxidative stress DNA Damage |
| Zdroj: | Journal of Agricultural and Food Chemistry. 55:9811-9816 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/jf071752g |
| Popis: | The effects of 24 h supplementation of human colon carcinoma cells (Caco-2) with isoflavones, genistein, and daidzein and their activities against oleic acid hydroperoxide mediated oxidative stress were investigated. Genistein, at 25, 50, and 100 microM, and daidzein, at 25 and 50 microM, did not induce cell injury to Caco-2 cells. Both compounds reduced cell injury and DNA damage mediated by 5 microM oleic acid hydroperoxides in Caco-2 cells. The effects of genistein and daidzein on antioxidant enzymes were dependent upon the compound and its concentration. |
| Databáze: | OpenAIRE |
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