Morphometry and Modeling of Label-Free Human Melanocytes and Melanoma Cells
| Autor: | Behnaz Shojaedin-Givi, Sharareh Tavaddod, Hossein Naderi-Manesh, Mahnaz Mahmoudirad |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
030102 biochemistry & molecular biology Chemistry Melanoma Pharmacology toxicology Significant difference Biophysics Cell Biology General Medicine Cell cycle Melanocyte medicine.disease Biochemistry Cell biology 03 medical and health sciences Nuclear body 030104 developmental biology medicine.anatomical_structure medicine Cell shape Label free |
| Zdroj: | Tavaddod, S, Shojaedin-Givi, B, Mahmoudi-Rad, M & Naderi-Manesh, H 2021, ' Morphometry and Modeling of Label-Free Human Melanocytes and Melanoma Cells. ', Cell biochemistry and biophysics, vol. 2021, pp. 1-8 . https://doi.org/10.1007/s12013-020-00963-w |
| ISSN: | 1559-0283 1085-9195 |
| Popis: | A combination of light microscopy and image processing was applied to investigate morphology of label-free primary-melanocytes and melanoma cells. A novel methodological approach based on morphology of nuclear body was used to find those single cells, which were at the same phase of cell cycle. The area and perimeter of melanocytes and melanoma cells were quantified. We found that there was a significant difference between area and perimeter of adendritic-shaped melanocytes with melanoma cells and the reason(s) of this finding was speculated. Finally, a theoretical model based on losing dendrites was proposed, which was in agreement with our experimental data. |
| Databáze: | OpenAIRE |
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