Quantitative 35Cl Nuclear Quadrupole Resonance in Tablets of the Antidiabetic Medicine Diabinese

Autor:	Pearce Gareth Edward Stephen, Stephen A.C. Wren, Michael D. Rowe, John A. S. Smith, Jamie Barras, Elizabeth Tate, Kaspar Althoefer
Rok vydání:	2009
Předmět:	Chlorpropamide Magnetic Resonance Spectroscopy Nuclear magnetic resonance Radio Waves Chemistry Isotope Labeling Hypoglycemic Agents Chlorine Nuclear quadrupole resonance Tablets Analytical Chemistry
Zdroj:	Analytical Chemistry. 81:5574-5576
ISSN:	1520-6882 0003-2700
DOI:	10.1021/ac900656e
Popis:	Pulsed (35)Cl nuclear quadrupole resonance (NQR) experiments have been performed on 250-mg tablets of the antidiabetic medicine Diabinese to establish the conditions needed for noninvasive quantitative analysis of the medicine in standard bottles. One important condition is the generation of a uniform radio-frequency (RF) field over the sample, which has been achieved by two designs of sample coil: one of variable pitch, and the other a resonator that has been fabricated from a single turn of copper sheet with a longitudinal gap bridged by tuning capacitors. The results from blind tests show that the number of tablets in a bottle could be predicted to within +/-3%.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e4c7411a2c9dc48f99ff3f3e04d87e https://doi.org/10.1021/ac900656e Zobrazit plný text záznamu