Promising therapeutic potential of pterostilbene and its mechanistic insight based on preclinical evidence
| Autor: | Sanjay Singh, Abhishank Singh, Uddipak Rai, Ramoji Kosuru, Swati Prakash |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Drug Pterostilbene media_common.quotation_subject Pharmacology Resveratrol Neuroprotection 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In vivo Central Nervous System Diseases Neoplasms Stilbenes Medicine Animals Humans media_common business.industry Bioavailability 030104 developmental biology chemistry Cardiovascular Diseases 030220 oncology & carcinogenesis Pharmacodynamics Pharmacokinetic aspects Safety business |
| Zdroj: | European journal of pharmacology. 789 |
| ISSN: | 1879-0712 |
| Popis: | Pterostilbene (PS) is a well-recognized antioxidant that primarily exists in blueberries, grapevines and heartwood of red sandalwood. Interest in this compound has been renewed in recent years, and studies have found that PS possesses an array of pharmacological properties, including chemopreventive, antiinflammatory, antidiabetic, antidyslipidemic, antiatherosclerotic and neuroprotective effects. However, the greater in vivo bioavailability of PS, as compared to resveratrol, is an added advantage for its efficacy. This review provides a summary regarding the sources, pharmacokinetic aspects and pharmacodynamics of PS, with a focus on the molecular mechanisms underlying its protective effects against cancer, brain injuries and heart disease. Studies regarding the safety profile of PS have also been included. Based on the presently available evidence, we conclude that PS represents an active phytonutrient and a potential drug with pleiotropic health applications. |
| Databáze: | OpenAIRE |
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