Quantitative nuclear magnetic resonance of chloride by an accurate internal standard approach

Autor:	Jared S. Wood, Guilherme Dal Poggetto, Xiao Wang, Mikhail Reibarkh, R. Thomas Williamson, Ryan D. Cohen
Rok vydání:	2022
Předmět:	Magnetic Resonance Spectroscopy Chlorides Solubility Pharmaceutical Preparations General Materials Science General Chemistry Chromatography High Pressure Liquid
Zdroj:	Magnetic Resonance in Chemistry. 61:22-31
ISSN:	1097-458X 0749-1581
Popis:	Chloride is the most common counterion used to improve aqueous solubility and enhance stability of small molecule active pharmaceutical ingredients. While several analytical techniques, such as titration, HPLC with charged aerosol detection, and ion chromatography, are currently utilized to assay the level of chloride, they have notable limitations, and these instruments may not be readily available. Here, we present a generally applicable
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e2721b1f27230dee6b7ba1c4e13e1f https://doi.org/10.1002/mrc.5316 Zobrazit plný text záznamu Plný text