Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation
| Autor: | Chiang Ch, Russell L. Margolis, Nadine Yoritomo, Guo Li Ming, Christopher A. Ross, Hongjun Song, Zhexing Wen, Yijing Su |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
Pluripotent Stem Cells Somatic cell DNA Mutational Analysis Nerve Tissue Proteins Article Cellular and Molecular Neuroscience DISC1 Humans Progenitor cell Induced pluripotent stem cell Molecular Biology Genetics Disease gene Homeodomain Proteins Induced stem cells biology Nanog Homeobox Protein Brain disease Psychiatry and Mental health Mutation biology.protein Schizophrenia Female Neuroscience Octamer Transcription Factor-3 |
| Popis: | Schizophrenia, a severe brain disease with a prominent genetic basis, has been suggested to have a neurodevelopmental origin.1 Although many candidate susceptibility genes for schizophrenia have been identified,2 access to human neural progenitors and neurons to study the biology of disease genes is very limited. Induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells of healthy subjects and patients,3 offer an unprecedented opportunity to recapitulate both normal and pathologic human development, thereby enabling a new approach to understanding human disease mechanisms. |
| Databáze: | OpenAIRE |
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