From tip to toe - dressing centrioles in γTuRC
| Autor: | Jens Lüders, Nina Schweizer |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Centrosome
0303 health sciences Centriole Cilium Cell Biology Biology Toes Bandages Microtubules Cell biology 03 medical and health sciences 0302 clinical medicine Microtubule Tubulin Ciliogenesis Humans Microtubule anchoring 030217 neurology & neurosurgery 030304 developmental biology Pericentriolar material Microtubule nucleation Centrioles |
| Zdroj: | Journal of cell science. 134(14) |
| ISSN: | 1477-9137 |
| Popis: | Centrioles are microtubule-based cylindrical structures that assemble the centrosome and template the formation of cilia. The proximal part of centrioles is associated with the pericentriolar material, a protein scaffold from which microtubules are nucleated. This activity is mediated by the γ-tubulin ring complex (γTuRC) whose central role in centrosomal microtubule organization has been recognized for decades. However, accumulating evidence suggests that γTuRC activity at this organelle is neither restricted to the pericentriolar material nor limited to microtubule nucleation. Instead, γTuRC is found along the entire centriole cylinder, at subdistal appendages, and inside the centriole lumen, where its canonical function as a microtubule nucleator might be supplemented or replaced by a function in microtubule anchoring and centriole stabilization, respectively. In this Opinion, we discuss recent insights into the expanded repertoire of γTuRC activities at centrioles and how distinct subpopulations of γTuRC might act in concert to ensure centrosome and cilia biogenesis and function, ultimately supporting cell proliferation, differentiation and homeostasis. We propose that the classical view of centrosomal γTuRC as a pericentriolar material-associated microtubule nucleator needs to be revised. |
| Databáze: | OpenAIRE |
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