Selective stimulation of insulin secretion by CCK-4 analogues having N-terminal modifications
| Autor: | K.B. Mathur, Mohammed Mubin Khan, Anil K. Rastogi, Jalil R. Kidwai, Bijoy Kundu, Faiyaz Ahmad |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Peptide Biology In Vitro Techniques Glucagon Sincalide Tetragastrin Islets of Langerhans Structure-Activity Relationship Endocrinology Internal medicine Insulin Secretion Internal Medicine medicine CCK-4 Animals Insulin Cholecystokinin chemistry.chemical_classification digestive oral and skin physiology Glucagon secretion Biological activity Rats Inbred Strains General Medicine In vitro Rats Kinetics Glucose chemistry hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Acta diabetologica latina. 28(1) |
| ISSN: | 0001-5563 |
| Popis: | Synthetic analogues of CCK-4 in which Trp was replaced by D-Pro (peptide I), Thz (peptide II) and delta Pro (peptide III) have been studied for their insulin and glucagon releasing activities from the islets of Langerhans in vitro. Peptide I has been found to be the most potent insulin releaser among the three analogues and its activity is comparable to that of CCK-4. Unlike CCK-4, its three analogues (peptides I-III) do not stimulate the release of glucagon with basal concentration of glucose in the medium. However, with increasing glucose concentration, all the three analogues potentiate the glucose stimulus for insulin release. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|