Neuroprotective Action of Amidic Neurolipins in Models of Neurotoxicity on the Culture of Human Neural-Like Cells SH-SY5Y
| Autor: | Vladimir V. Bezuglov, M. G. Akimov, Fomina-Ageeva Ev, N. F. Myasoedov, A. M. Ashba, Natalia Gretskaya |
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| Rok vydání: | 2019 |
| Předmět: |
SH-SY5Y
Fatty Acids Neurodegeneration Biophysics Neurotoxicity Neurodegenerative Diseases General Chemistry General Medicine Pharmacology medicine.disease Amides Biochemistry Neuroprotection Cell Line chemistry.chemical_compound Neuroprotective Agents chemistry Cell culture Docosahexaenoic acid Amide medicine Humans Signal Transduction |
| Zdroj: | Doklady Biochemistry and Biophysics. 485:141-144 |
| ISSN: | 1608-3091 1607-6729 |
| Popis: | It was established that in neurodegeneration models in the human neuron-like cell line SH-SY5Y, amide derivatives of arachidonic and docosahexaenoic acids were inactive in experiments with MPP+ and CoCl2 but protected from H2O2. The protective activity of neurolipins decreased in the series DHA-DA > AA-SER ≥ AA-GLY > AA-GABA ≥ AA-EA and was manifested starting from a concentration of 0.5 nM. |
| Databáze: | OpenAIRE |
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