Multimodal wrist-worn devices for seizure detection and advancing research: Focus on the Empatica wristbands
| Autor: | Rosalind W. Picard, Matteo Lai, Francesco Onorati, Giulia Regalia, Chiara Caborni |
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| Přispěvatelé: | Massachusetts Institute of Technology. Media Laboratory |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Biomedical Research Computer science Wearable computer Clinical settings Unexpected death Constant false alarm rate Machine Learning 03 medical and health sciences Epilepsy Wearable Electronic Devices 0302 clinical medicine Physical medicine and rehabilitation Seizures medicine Humans Longitudinal Studies Focus (computing) Clinical Trials as Topic Electroencephalography Galvanic Skin Response Wrist medicine.disease Data availability 030104 developmental biology Neurology Seizure detection Neurology (clinical) 030217 neurology & neurosurgery |
| Zdroj: | Prof. Picard via Elizabeth Soergel |
| Popis: | Wearable automated seizure detection devices offer a high potential to improve seizure management, through continuous ambulatory monitoring, accurate seizure counts, and real-time alerts for prompt intervention. More importantly, these devices can be a life-saving help for people with a higher risk of sudden unexpected death in epilepsy (SUDEP), especially in case of generalized tonic-clonic seizures (GTCS). The Embrace and E4 wristbands (Empatica) are the first commercially available multimodal wristbands that were designed to sense the physiological hallmarks of ongoing GTCS: while Embrace only embeds a machine learning-based detection algorithm, both E4 and Embrace devices are equipped with motion (accelerometers, ACC) and electrodermal activity (EDA) sensors and both the devices received medical clearance (E4 from EU CE, Embrace from EU CE and US FDA). The aim of this contribution is to provide updated evidence of the effectiveness of GTCS detection and monitoring relying on the combination of ACM and EDA sensors. A machine learning algorithm able to recognize ACC and EDA signatures of GTCS-like events has been developed on E4 data, labeled using gold-standard video-EEG examined by epileptologists in clinical centers, and has undergone continuous improvement. While keeping an elevated sensitivity to GTCS (92–100%), algorithm improvements and growing data availability led to lower false alarm rate (FAR) from the initial ˜2 down to 0.2–1 false alarms per day, as showed by retrospective and prospective analyses in inpatient settings. Algorithm adjustment to better discriminate real-life physical activities from GTCS, has brought the initial FAR of ˜6 on outpatient real life settings, down to values comparable to best-case clinical settings (FAR |
| Databáze: | OpenAIRE |
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