The effects of nattokinase supplementation on collagen–epinephrine closure time, prothrombin time and activated partial thromboplastin time in nondiabetic and hypercholesterolemic subjects
| Autor: | Chunmei Jin, Sanghyun Lee, Ayoung Lee, Tae Su Kim, Jong Ho Lee, Hye Jin Yoo, Minjoo Kim, Minkyung Kim, Sung Pyo Lee |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Epinephrine Hypercholesterolemia Closure (topology) 03 medical and health sciences chemistry.chemical_compound medicine Epinephrine metabolism Humans Subtilisins Aged Prothrombin time 030109 nutrition & dietetics medicine.diagnostic_test business.industry Soy Foods General Medicine Middle Aged 030104 developmental biology chemistry Anesthesia Dietary Supplements Collagen metabolism Prothrombin Time Female Partial Thromboplastin Time Collagen business Nattokinase Food Science Partial thromboplastin time medicine.drug |
| Zdroj: | Food & Function. 10:2888-2893 |
| ISSN: | 2042-650X 2042-6496 |
| DOI: | 10.1039/c8fo02324g |
| Popis: | The aim of this study was to investigate whether supplementation with nattokinase, which is considered one of the most active functional ingredients found in natto, alters hemostatic factors. Subjects presenting with hypercholesterolemia (serum cholesterol: 200-280 mg dL-1) were randomly divided into nattokinase and placebo groups (n = 50, respectively). No significant between-group differences were found at baseline in collagen-epinephrine closure time (C-EPI CT), prothrombin time (PT), or activated partial thromboplastin time (aPTT). After 8 weeks of treatment, the nattokinase group exhibited significant increases in C-EPI CT, PT, and aPTT. The nattokinase group showed significantly greater increases in C-EPI CT (P = 0.001) and aPTT (P = 0.016) than the placebo group. Moreover, at 8 weeks, the nattokinase group showed a significantly higher C-EPI CT than the placebo group (P = 0.001). Additionally, a significant correlation between PT and aPTT was observed (r = 0.491, P0.001). In conclusion, nattokinase supplementation was associated with prolonged C-EPI CT and aPTT in nondiabetic and borderline-to-moderate hypercholesterolemic subjects. |
| Databáze: | OpenAIRE |
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