Novel antimicrobial peptides that exhibit activity against select agents and other drug resistant bacteria
| Autor: | Rickey P. Hicks, Brittany C. Williams, Allen J. Mueller, Antoine H. Srouji, Jayendra B. Bhonsle, David G. Klapper, Divakaramenon Venugopal, Richard Borschel, Amanda L. Russell |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Models
Molecular Modern medicine Clinical Biochemistry Antimicrobial peptides Pharmaceutical Science Microbial Sensitivity Tests Drug resistance Biochemistry Microbiology chemistry.chemical_compound Antibiotic resistance Drug Resistance Bacterial Drug Discovery Peptide synthesis Molecular Biology Antibacterial agent Bacteria biology Chemistry Organic Chemistry Fluoresceins Antimicrobial biology.organism_classification Anti-Bacterial Agents Liposomes Molecular Medicine Peptides |
| Zdroj: | Bioorganic & Medicinal Chemistry. 18:5137-5147 |
| ISSN: | 0968-0896 |
| Popis: | One of the greatest challenges facing modern medicine is the evolution of drug resistant strains of bacteria. In addition to traditional methods of exposure to traditional bacterial organisms there is a growing concerned of the use of bacteria as bio-terrorism agents. To counter the evolution of drug resistant and potential bio-terrorism bacterial agents new antibiotic drugs must be developed. One potential source of new therapeutic agents that act via a novel mechanism of action are natural and synthetic antimicrobial peptides (AMPs). In our laboratories we have developed a series of AMPs incorporating the un-natural amino acids Tic-Oic to impart organism selectivity and potency while increasing metabolic stability. Herein the in vitro activity of these peptides, including ten new compounds, against eight potential bio-terrorism bacterial agents and three other bacterial strains is presented and discussed. These peptides exhibit a wide range of organism potency and selectivity. Calcein fluorescence leakage and circular dichroism studies were conducted to confirm that these peptides interact with zwitterionic and anionic liposomes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect