LDL subclass lipidomics in atherogenic dyslipidemia: effect of statin therapy on bioactive lipids and dense LDL

Autor: Peter J. Meikle, Patrice Thérond, Alexina Orsoni, Ricardo Tan, Philippe Giral, Paul Robillard, Anh Nguyen, M. John Chapman, Natalie A. Mellett
Přispěvatelé: Service d’Endocrinologie, Métabolisme et Prévention des Risques Cardio-Vasculaires [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Biochimie [AP-HP Hôpital Bicêtre], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Baker Heart and Diabetes Institute (AUSTRALIA), Unité de recherche sur les maladies cardiovasculaires et métaboliques, UMR S 1166, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)
Rok vydání: 2020
Předmět:
Male
vsdLDL
GM3
0301 basic medicine
Apolipoprotein B
[SDV]Life Sciences [q-bio]
alkenylphosphatidylethanolamine
Lp-PLA2
030204 cardiovascular system & hematology
lysophosphatidylinositol
Biochemistry
trihexosylceramide
chemistry.chemical_compound
PC(O)
low density lipoprotein subclass heterogeneity
0302 clinical medicine
Endocrinology
Lp(a)
monosialodihexosylganglioside
Abbreviations: ASCVD
MetS
very small dense LDL
dhCer
small dense LDL
alkylphosphatidylcholine
Cer
biology
interleukin
isopycnic density gradient ultracentrifugation
Lipoprotein(a)
Middle Aged
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
alkenylphosphatidylcholine
CE
Lipoproteins
LDL
PC(P)
DHC
Low-density lipoprotein
cholesteryl ester
Lysophosphatidylinositol
LPI
Female
lipids (amino acids
peptides
and proteins)
atherosclerotic CVD
triacylglycerol
LPE
platelet-activating factor
medicine.medical_specialty
THC
LPC(O)
free cholesterol
cholesteryl ester transfer protein
monohexosylce- ramide
QD415-436
sdLDL
metabolic syndrome
alkylphosphatidylethanol- amine
pitavastatin calcium
lysophosphatidylcholine
PE(O)
dihydroceramide
03 medical and health sciences
Internal medicine
CETP
Cholesterylester transfer protein
Lipidomics
COH
medicine
Humans
ceramide
lipoprotein-associated phospholipase A2
Dyslipidemias
ceramides
Lipoprotein-associated phospholipase A2
lipoprotein (a)
PAF
IL
Cell Biology
Atherosclerosis
lysoalkylphosphatidylcholine
030104 developmental biology
dihexosylceramide
liquid chromatography electrospray ionization-tandem mass spectrometry
chemistry
TAG
PE(P)
biology.protein
Hydroxymethylglutaryl-CoA Reductase Inhibitors
MHC
Patient-Oriented and Epidemiological Research
low density lipoprotein
lysophosphatidylethanol- amine
Lipoprotein
Zdroj: Journal of Lipid Research
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2020, 61 (6), pp.911-932. ⟨10.1194/jlr.P119000543⟩
Journal of Lipid Research, Vol 61, Iss 6, Pp 911-932 (2020)
J Lipid Res
ISSN: 0022-2275
DOI: 10.1194/jlr.p119000543
Popis: International audience; Atherogenic LDL particles are physicochemically and metabolically heterogeneous. Can bioactive lipid cargo differentiate LDLsubclasses, and thus potential atherogenicity? What is the effect of statin treatment? Obese hypertriglyceridemic hypercholesterolemicmales [n = 12; lipoprotein (a)
Databáze: OpenAIRE
Externí odkaz: