Treatment trends and outcomes of hepatocellular carcinoma in a single center for 35 years
| Autor: | Olli Helminen, Vesa-Matti Pohjanen, Mira Karjalainen, Valtteri Kairaluoma, Juha Saarnio, Heikki Huhta, Jarmo Niemelä |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Carcinoma Hepatocellular Population Single Center Ablation techniques Causes of cancer Hepatectomy Humans Medicine Major complication education Retrospective Studies education.field_of_study Surgical procedures operative business.industry Proportional hazards model Carcinoma hepatocellular Liver Neoplasms Confounding medicine.disease University hospital Surgery Hepatocellular carcinoma Neoplasm Recurrence Local business |
| Popis: | Background: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality. The aim of this study was to examine the trends of HCC treatment and the outcomes in a single tertiary center for 35 years. Methods: Two hundred seventy–three consecutive HCC patients between 1983–2018 were identified from Oulu University Hospital records. Primary outcomes of the study were postoperative complications within 30 days after the operation, and short– (30–and 90–day) and long-term (1, 3 and 5–year) survival. Results: Of the 273 patients, 49 underwent surgical resection, 25 local ablation, 48 angiological treatment and 151 had palliative treatment. The rate of surgery declined over time, while other invasive treatments increased. Major complications occurred in 14 (28.6%) patients after surgical resection, in 2 (8.0%) patients after local ablation and in 13 (27.1%) patients after angiological treatment (P=0.022). Recurrence and local recidives were observed especially in local ablation group and in angiological treatment group (P |
| Databáze: | OpenAIRE |
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