Assessment of ST2 and Reg3a levels in patients with acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
| Autor: | Umit Akman, Yahya Buyukasik, Umit Yavuz Malkan, Elifcan Aladağ Karakulak, Hakan Goker, Haluk Demiroglu |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Graft vs Host Disease Pancreatitis-Associated Proteins Disease Hematopoietic stem cell transplantation Gastroenterology Suppression of tumorigenicity 2 Article Predictive Value of Tests Internal medicine graft-versus-host disease Medicine Humans Transplantation Homologous allogeneic hematopoietic stem cell transplantation Leukemia business.industry regenerating isletderived 3-alpha Hematopoietic Stem Cell Transplantation General Medicine medicine.disease Prognosis Interleukin-1 Receptor-Like 1 Protein Transplantation Graft-versus-host disease surgical procedures operative Biomarker (medicine) Population study Female Stem cell business Complication Biomarkers |
| Zdroj: | Turkish Journal of Medical Sciences |
| ISSN: | 1303-6165 |
| Popis: | Background/aim Graft-versus-host disease (GVHD) is a crucial complication leading to significant morbidity and mortality allogeneic hematopoietic stem cell transplantation which occurs in approximately half of the transplant recipients. Suppression of tumorigenicity 2 (ST2) and regenerating islet-derived 3-alpha(Reg3a) might be important biomarkers to predict acute GVHD. Materials and methods In the present study, blood samples were collected from 17 patients with acute GVHD and 12 control patients after allogeneic stem cell transplantation. ST2 and Reg3a were measured in plasma samples compared in patients with acute GVHD and the controls. Results Median age of the study population was 42 years (range 19–49). When compared to controls, the mean ST2 levels was significant higher in acute GVHD (9794 ng/dL vs. 2646 ng/dL, P = 0.008). Mean Reg3a level did not show significant difference between control and acute GVHD group (8848 ng/dL vs. 5632 ng/dL, respectively, P = 0.190). Conclusion The ST2 level might be used as a significant biomarker for predicting acute GVHD. |
| Databáze: | OpenAIRE |
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