Adolescent chronic restraint stress (aCRS) elicits robust depressive-like behavior in freely cycling, adult female rats without increasing anxiety-like behaviors
| Autor: | Martha Graham, Meghan Hibicke, Renée L Hayslett |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Restraint
Physical Elevated plus maze medicine.medical_treatment 030508 substance abuse Physiology Antidepressive Agents Tricyclic Weight Gain Open field Rats Sprague-Dawley 03 medical and health sciences Risk Factors Desipramine medicine Animals Pharmacology (medical) Maze Learning Saline Pharmacology Depressive Disorder Major Behavior Animal Depression business.industry Age Factors 0402 animal and dairy science 04 agricultural and veterinary sciences medicine.disease 040201 dairy & animal science Rats Disease Models Animal Psychiatry and Mental health Mood Major depressive disorder Female medicine.symptom 0305 other medical science business Weight gain Stress Psychological Behavioural despair test medicine.drug |
| Zdroj: | Experimental and Clinical Psychopharmacology. 25:74-83 |
| ISSN: | 1936-2293 1064-1297 |
| DOI: | 10.1037/pha0000119 |
| Popis: | Stress during times of rapid development is a risk factor for Major Depressive Disorder, a mood disorder that disproportionately affects women. We developed an adolescent chronic restraint stress (aCRS) protocol using female rats to address the impact of adolescent stress on female adult depressive-like behavior. Animals were divided into 4 treatment groups: not restrained:saline (NRSAL), not restrained:desipramine (NRDES), restrained:saline (RSAL), and restrained:desipramine (RDES). NRSAL and NRDES rats were housed in a separate colony room from RSAL and RDES rats. All animals were weighed and handled daily. Beginning postnatal day (PND) 34(±1), RSAL and RDES rats were restrained for 1 hour daily for 14 consecutive days. Beginning PND 55(±1), NRDES and RDES rats were given subcutaneous desipramine (5 mg/kg), which served as a positive control, daily for 14 consecutive days. During that same time period, NRSAL and RSAL rats were given subcutaneous saline daily. aCRS (RSAL and RDES) rats showed significantly attenuated weight gain compared with nonrestrained (NRSAL and NRDES) rats during the restraint period. Weight gain normalized after the final restraint session. Behavioral testing took place PND 68-69(±1), and included open field testing, the elevated plus maze, locomotor activity, and the forced swim test (FST). RSAL rats showed significantly more immobility in the FST versus all other groups, indicating depressive-like behavior. No differences between groups were observed in the other behavioral measures. These results indicate that aCRS elicits depressive-like behavioral characteristics in adult female rats without increasing anxiety-like behaviors. (PsycINFO Database Record |
| Databáze: | OpenAIRE |
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